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Study cohort included consecutive AIS patients undergoing i. Blood samples taken on admission, immediately after and 24 h after therapy were analyzed for FXIII activity and antigen levels.
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Val34Leu, p. Long-term functional outcome was defined at 3 months post-event by the modified Rankin scale.
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FXIII levels showed a gradual decrease immediately after thrombolysis and 24 h later, which was not related to therapy-associated bleeding. In a multiple logistic regression model, a FXIII level in the lowest quartile 24 h post-lysis proved to be an independent predictor of mortality by 14 days post-event OR In conclusion, our findings indicate that FXIII levels 24 h after thrombolysis might help to identify patients at increased risk for short-term mortality.
Introduction Acute ischemic stroke AIS is a leading cause of death or disability in all developed countries 1. Today, the most effective pharmacological therapy to improve functional outcomes is the lysis of thrombi using recombinant tissue plasminogen activator rtPA within 4.
Although this intervention has been used for many decades, little is known why in some project on diabetes thrombolysis is less efficient and which are the factors promoting non-desirable side effects in others.
In a subset of patients thrombolytic therapy is inefficient due can high blood sugar trigger afib the failure of recanalization of the closed vessel and no clinical improvement is observed 3. In most cases, these complications cannot be foreseen at the initiation of therapy and their occurrence remains unexplained. It is plausible that effectiveness as well as adverse effects of the thrombolytic agent could depend on hemostatic and fibrinolytic factors influencing the structure of thrombi and the susceptibility to lysis.
Cardiology - Effects of impaired glucose metabolism on hemorheological parameters and platelet aggregation Supervisor: KOLTAI, Katalin Rheological factors and increased platelet aggregation are convincingly implicated in the development of micro- and macrovascular diseases associated with diabetes mellitus. Glycemic control seems to be a major factor to determine the hemorheological consequences of diabetes. Positive associations have been found between parameters of glycemic control, fibrinogen levels and red blood cell aggregation; fibrinogen levels are also correlated to insulin resistance. The binding of fibrinogen to the GP IIb-IIIa receptor is increased in diabetic patients; and they also have a higher ratio of platelets expressing activation-dependent adhesion molecules such as activated GPIIb-IIIa, lysosomal Gp53, thrombospondin and P-selectin; plasma fibrinogen levels are also increased in diabetes. Platelets may interact with glycosylated low density lipoproteins, von Willebrand factor or immune complexes, and platelet turnover may be shortened in diabetes, thereby contributing to the observation that antiplatelet agents such as aspirin and clopidogrel have a diminished effect in these patients.
With the introduction of mechanical thrombectomy in the management of acute stroke care, today it is becoming important to identify patients who are at risk of worse thrombolysis outcomes and would benefit from alternative treatments 4. The active form FXIIIa plays a crucial role in protecting the clot against prompt fibrinolytic degradation, which is achieved by at least three major ways.
First, FXIIIa cross-links α2-plasmin inhibitor α2-PI and perhaps other plasma components to fibrin, which effectively hinders its proteolytic degradation by plasmin.
Second, FXIIIa cross-links fibrin α-chains into a high molecular weight α-polymers, which most likely has a direct effect on the susceptibility of fibrin clot to lysis.
Diabetes Stroke Diet
Third, cross-linking of fibrin by FXIIIa decreases the binding of plasminogen to fibrin, and consequently, decreases plasminogen activation by tPA 9. On the other hand, deficiency of FXIII leads to a life-long bleeding disorder and in many cases severe or fatal intracranial hemorrhage is a prominent feature of the disease TyrPhe, p.
Amerika növekvő elhízási aránya az elöregedő népességünkkel együtt felvetette azt az aggodalmat, hogy a cukorbetegség több mint a szívbetegségek kockázati tényezője; a szívelégtelenség és a cukorbetegség kapcsolata halálos. A CDC azt állítja több mint 30 millió ember él az Egyesült Államokban millió világszerte cukorbeteg, és 1 ban ben 4 közülük nem tudják, hogy megvan. Az Egészségügyi Világszervezet WHO arról számol be, hogy azóta a cukorbetegek száma majdnem megnégyszereződött az elhízás és a széles körű fizikai aktivitás miatt.
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Val34Leu with the risk of thrombotic diseases has been intensively investigated 569. Results Study population Baseline characteristics of patients and stroke outcomes are summarized in Table 1.
A total of consecutive AIS patients undergoing thrombolysis were included in the study.
Mean age was Average time from symptom onset to treatment with rtPA was less than 3 h in the cohort and the duration of thrombolysis was approximately one hour for each patient. In case of 7 patients intravenous thrombolytic therapy was supplemented with intraarterial thrombolysis according to the standard protocol; the final dose of rtPA and the duration of thrombolysis was not significantly different for these patients as compared to the rest of the study group.
Table 1 Baseline characteristics and outcomes of patients.