Wolfram syndrome Summary The Wolfram syndrome is a rare disorder with an autosomal recessive inheritance. The symptoms develop as a consequence of a progressive neurodegenerative process.
The first manifestation of the syndrome is a childhood onset diabetes mellitus followed by diabetes insipidus, optic nerve atrophy, hearing impairment, and dilation of the urinary tract each case in a different sequence.
Treatment of the disease is determined by the current symptoms.
By virtue of its multifacetedness, it requires the concerted actions of care from different professions. Bennett, PH: Classification and diagnosis of diabetes mellitus and impaired glucose tolerance.
In: Textbook of diabetes. Harris, MI, Zimmet, P: Classification of diabetes mellitus and other categories of glucose intolerance. In: International textbook of diabetes mellitus.
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