Drug induced hyperglycemia and diabetes


Modeling long-term diabetes and related complications in rats J Pharmacol Toxicol Methods.

Mar-Apr ; Epub Nov Gyömrői út Electronic address: erika. DOI: The aims of this study were to establish a model of long-term diabetes with sustained medium scale hyperglycemia and characterize the pathological changes detectable after 4months, with particular respect to dependence on the degree of hyperglycemia.

Protective effects of the novel amine-oxidase inhibitor multi-target drug SZV on streptozotocin-induced beta cell damage and diabetic complications in rats Biomed Pharmacother.

Methods: Streptozotocin-induced diabetic CFY rats were subjected to four different insulin substitution protocols to achieve different levels of glycemic control Diabetic groups. Eyes were investigated by ophthalmoscopy, kidney function by urine analysis, and neuropathy by functional tests.

ginger receptek diabétesz kezelésére tej és a cukorbetegség

Retinal and renal morphological evaluations were performed by histology, immuno-histochemistry and electron microscopy. Discussion: We established a treatment protocol in rats enabling complex investigation of diabetic retinopathy, nephropathy and neuropathy on a long-term period.

Стратмор продолжал спуск. Сделка отменяется. «Нуматек корпорейшн» никогда не получит невзламываемый алгоритм… а агентство - «черный ход» в «Цифровую крепость».

Clearly hyperglycemic dependent parameters of these complications serve as good outcome measures for preclinical trials.

Our results provide a useful basis for designing studies for testing preventative treatments as well as other translational medical research in this field.

kukorica kezelés diabetes rubeosis iridis diabetic eye

Keywords: Anterior segment neovascularization; Chronic model; Cold allodynia; Diabetic nephropathy; Diabetic neuropathy; Diabetic retinopathy; Drug development; Insulin implant; Preclinical model; Streptozotocin. Copyright © Elsevier Inc. All rights reserved.

sah diabetes 2 típusú tabletták kezelése 2 es típusú cukorbetegség inzulin

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